b'EARLY CAREER RESEARCHER GRANTN TImmune Mechanisms Underlying The Rapid Anti-suicidal Effects of Electroconvulsive Therapy and KetamineMina Rizk, M.D.Icahn School of Medicine at Mount SinaiMentor: James Murrough, M.D., Ph.D. Icahn School of Medicine at Mount Sinai$140,000Electroconvulsive therapy (ECT) and intravenous ketamine are two effective treatments for individuals suffering from depression and an acute suicidal crisis. Abnormalities of the immune system are linked to suicide risk and can be modulated by ECT and ketamine. This study aims to understand if the biological effects of ECT and ketamine on the immune system are related to their clinical effects on suicidal thoughts in people with major depression. 34'