b'LINKED STANDARDRESEARCHGRANTNBrain-Relevant Molecules in the BloodMarie Gaine, Ph.D.University of Iowa Sarven Sabunciyan, Ph.D.Johns Hopkins University$449,999The biological basis of suicide remains incompletely understood, partly due to the inaccessibility of the brain. This study utilizes easily accessible samples from blood to study extracellular vesicles and cell-free DNA that may reflect changes in the brain that are also associated with suicide. The goal in this proposal is to further our understanding of suicidal thoughts and behaviors, and to identify molecular targets for the identification of individuals at high risk. 13'